As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
An email apparently sent by the Guardians of Peace includes a link to a YouTube video that refers to the investigators as idiots Read More
The queen of pop strikes back at demo leaks, announces "Rebel Heart" Read More
"If Kim Jong Un and his henchmen were upset before, wait till they see the movie we're going to make," Larry Flynt says Read More
THR pays tribute to Hollywood figures who died this year View gallery
Judy Smith is a crisis management expert and the inspiration for the ABC show's Olivia Pope Read More
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