As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
THR was on the stages of CBS' comedy juggernaut during the series' fifth season. View gallery
"We're in a very different spot and everybody has been wiped clean, and anything goes, in a weird way," the showrunner tells THR. Read More
THR pays tribute to Hollywood figures who died this year. View gallery
A handy guide to keep up with which scripted and reality offerings will return to the broadcast networks next season. View gallery
The CBS comedy has had its fair share of geek gods pop by. View gallery
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