As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
In an exclusive book excerpt, Tina Fey, Amy Poehler and even Sarah Palin recount the inner battle between the left and right Read More
Bryan Cranston and Aaron Paul play lecherous pawn-shop owners as the "Veep" star tries to raise funds for the island she just bought Read More
THR pays tribute to Hollywood figures who died this year View gallery
The fourth season of the FX anthology will premiere in October; plus watch the first teaser Read More
The 'Cosby Show' legend and Camille, his wife of 50 years, have enjoyed many happy moments, along with enduring the tragic death of their son Ennis View gallery
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