As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
At the the same time, Fox takes 'Assassin's Creed' off the summer 2015 calendar, while shifting 'The Fantastic Four' and 'Paper Towns' Read More
Ahead of the Sept. 28 return, Adam Horowitz and Eddy Kitsis help THR break down the new season Read More
THR pays tribute to Hollywood figures who died this year View gallery
A handy guide to keep up with which scripted and reality offerings will return to the broadcast networks next season. View gallery
Octavia Spencer, Katherine Heigl, Ben McKenzie and Terrence Howard star in new series debuting on the major networks. View gallery
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