As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
The boy king everyone loves to hate likes crossbows, beheadings and... View gallery
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Mark Wahlberg’s F-bombs, Jonah Hill's slam and Zac Efron’s abs ... View gallery
THR pays tribute to Hollywood figures who died this year. View gallery
Lana Del Rey, Outkast and Lorde were among the highlights of the Ca... View gallery
The boy king everyone loves to hate likes crossbows, beheadings and tormenting Starks far too much for anyone's good. View gallery
We all know "A Lannister always pays his debts" -- but the HBO hit has spawned many other phrases that deserve to be just as famous. View gallery
Mark Wahlberg’s F-bombs, Jonah Hill's slam and Zac Efron’s abs were among the highlights of the Nokia Theater ceremony, hosted by Conan O’Brien and featuring performances by Rihanna, Eminem and Ellie Goulding. View gallery
Ben Affleck stars as a man under suspicion of killing his wife in the adaptation of Gillian Flynn's popular book. Watch video
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