As the talk show host's 25-year-long show ends, THR highlights the most memorable moments.
Tom Cruise shocked Oprah and the world when he now-infamously declared his love for soon-to-be wife Katie Holmes in 2005 by declaring "I'm in love" and jumping up and down on her couch.
Aided by guest John Travolta (a Qantas pilot) the Queen of Media shocked her studio audience last December by giving them a trip to Australia .
In December of 2009, Oprah shot a Christmas special at the White House with President Obama and the First Lady where she asked Michelle about her favorite gift.
In 1993, the King of Pop beatboxed and gave an impromptu performance for the talk show host during an exclusive interview.
Jennifer Hudson on 'The Oprah Winfrey Show'
Oscar winner and former American Idol contestant Jennifer Hudson talked weight loss, and broke her silence on the murder of her mother, brother and nephew, with Oprah in February 2011.
FNC celebrates a quarter with the most-watched primetime across the cable dial, while MSNBC slides below CNN in the demo Read More
Melissa and Winston Rauch will co-write 'If We're Not Married by 30' Read More
THR was on the stages of CBS' comedy juggernaut during the series' fifth season. View gallery
The Yousaf sisters conspired to remove Kris Trindl from the group, says a new lawsuit Read More
THR pays tribute to Hollywood figures who died this year View gallery
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