Ed Helms plays Pat, the older brother going through a marriage crisis and a renaissance in his relationship with his family.
Susan Sarandon features in Jeff as the mother of Ed Helms and Jason Segel who is going through her own crises.
From the moment he begins talking on a tape recorder about the meaning behind the movie Signs, Segel takes front and center as Jeff, a basement stoner with a heart of gold and a belief that the world will one day deliver to him a destiny.
Bobby Cannavale turned out to support the film; he'll next star in Lovelace and Movie 43.
The Top Chef star turned out for the film, and would have enjoyed the fare at the after-party.
The Saturday Night Live star checked in to see some buddies make comedy.
Jason Segel, Ed Helms
Jason Segel and Ed Helms play brothers Jeff and Pat, who don't always see eye to eye but seem to need each other during a desperate stretch that will decide both their fates.
Jason Segel, Jay Pharoah
Two of the funniest men on TV strike a dramatic pose together.
Jason Segel, Ed Helms, Judah Friedlander
The film's two stars joined up with 30 Rock's Judah Friedlander for some post-party fun. Friedlander did his best to dress up for the occasion.
Susan Sarandon, Padma Lakshmi
Sarandon and Lakshmi spent some time relaxing following the big premiere.
Samantha Mathis, Arden Myrin
American Psycho star Samantha Mathis and MadTV actress Arden Myrin took in the precedings and then the show.
The Hollywood Reporter's Scott Feinberg hosted a Q&A session for the audience after the screening.