Winona Ryder is reuniting with Daniel Waters, who wrote "Heathers" and helped establish Ryder as the edgy "it" girl for Generation X.

Ryder has signed on to star as a feminist vigilante who becomes an urban folk hero in "Sex and Death 101," which Waters wrote and is directing.

The story follows a man (Simon Baker) whose life is upended by a mysterious e-mail containing the 101 names of every woman he has had sex with and, eerily, every woman he will have sex with in the future. He is stopped in his tracks when he meets Ryder, a femme fatale who targets men guilty of sex crimes against women.

Julie Bowen ("Boston Legal") also has joined the cast and will play No. 29 on the long list of Baker's libidinous conquests. Dash Mihok ("Kiss Kiss, Bang Bang") is on board to play Lester, one of Baker's best friends.

Cary Brokaw's Avenue Pictures and Sandbar Pictures are producing and co-financing.

"('Sex and Death 101') is the first indie I've done in some time," Brokaw said. "I fell in love with the script -- it's smart, inventive and incredibly funny. It succeeds in being really funny, provocative and completely unpredictable, which for a romantic comedy is no small feat."

Brokaw also described the movie as a "hard R" for nudity, sex scenes and frequent references to sex.

Brokaw is producing with Sandbar's Lizzie Friedman and Greg Little. Avenue exec vp Aaron Craig Geller, who brought the project in, is serving as executive producer.

Daryn Okada is shooting the indie film, budgeted at less than $10 million, for Waters during the next 61⁄2 weeks on location in Los Angeles.

Ryder is managed by ThruLine Entertainment. Bowen is repped by UTA and Liberman/Zerman Management. Mihok is repped by Endeavor.