THR's Women in Entertainment 2012: Power 100

With Oprah Winfrey's daytime talk show a distant memory, DeGeneres now is delivering her highest ratings ever in her 10th season on the air. The married comedian, 54, who claims about 15 million Twitter followers, continues to broaden her reach with best-selling books, primetime series in development and another daytime offering from Real Housewives star Bethenny Frankel.

Moment I knew I wanted to work in the business: The first time I heard applause. It was from my mother. She was applauding for my brother Vance, but still.

Who gave me my first big break: Johnny Carson. All I had was a mullet and a dream when he invited me over to his couch.

Proudest moment this year: Hitting every green light on Moorpark between Coldwater and Cahuenga. And, winning the Mark Twain Award.

When I leave work each day, I can't wait to: Honk at cute firemen.

Favorite way to unwind on the weekend: Very personal. How dare you.

Can't get through my workday without: Admiring my butt in a mirror.

Embarrassed to admit I watch: The number of shows I watch. Too many to count.

Click here to read THR's complete Women in Entertainment list.