THR's Women in Entertainment 2012: Power 100

Berger, 48, is responsible for such guilty pleasures as the recently renewed Married to Jonas, Chelsea Lately and the longtime juggernaut Keeping Up With the Kardashians and its many spinoffs. In recent months, the married mother of two has been focused on pushing the newly rebranded network -- it's in the top 10 among women 18-to-49 -- into scripted fare as well.

Moment I knew I wanted to work in the business: When I saw the "Thriller" video on MTV. I saw the power of music on television, and that video, in its time, was such a breakthrough.

Who gave me my first big break: Judy McGrath at MTV. She trusted that we could go beyond music videos and put on original programming, and I was a part of that wave. She trusted me and the power of the MTV brand.

What I'd tell my 22-year-old self about working in Hollywood: "Always go with your gut and believe in the passion of the project and the people behind it."

Proudest accomplishment this year: Going through the rebrand of E!

When I leave work, I can't wait to: Go home and see my two girls, 12 and 9.

Can't get through my workday without: My double latte with one sugar.

Best advice I've ever gotten: "Don't be afraid to make decisions."

Toughest decision I had to make this year: It will be deciding on E!'s first scripted show.

Embarrassed to admit I watch: Dance Moms.

Click here to read THR's complete Women in Entertainment list.