THR's Women in Entertainment 2012: Power 100

Paulsen, 57, has raised more than $800 million for charity and made the EIF a major force in health activism with its Women's Cancer Research Fund, the Picture Quitting anti-smoking program and its Revlon Run/Walk for Women. The married mother of two also co-founded Stand Up to Cancer with Sherry Lansing and Katie Couric.

Moment I knew I wanted to work in the business: I volunteered at a charity event while doing an internship at NBC.

Who gave me my first big break: [Former Universal and Fox exec] Dan Slusser. He was the architect of my rise through the ranks at the EIF.

Favorite way to unwind on the weekend: Flying my glider plane. It's very poetic in the air.

One indulgence: Weekly mani and pedi at a salon in Manhattan Beach.

Proudest moment this year: After the Stand Up to Cancer telecast.

What I'd tell my 22-year-old self about working in Hollywood: "Always try to do what you say you're going to do."

Best advice I've ever gotten: From my dad: "Dream big and be real."

Embarrassed to admit I watch: The Real Housewives of New Jersey.

Click here to read THR's complete Women in Entertainment list.