THR's Women in Entertainment 2011: Power 100

Josephson has agenting in her blood -- literally. Still, the daughter of ICM's founder, Marvin Josephson, was intent on taking another route, starting her career as an entertainment lawyer. The catch? "I realized quickly that I was sort of an 'agent-y' lawyer," she says, explaining how she'd be more interested in bringing in new clients than assisting those of her bosses.

PHOTOS: 2011 Women in Entertainment Power 100

Once Josephson decided to make the career shift, she did so determined not to work at her father's shop. But when ICM heavyweight Sam Cohn caught wind of her circling a gig at Susan Smith's agency, he intervened and lured her to ICM. She later became the company's first female president before jumping to WME.

"Sam was absolutely my first mentor," she says, recalling one night when he dragged her to Don't Tell Mama, an off-the-beaten-path New York City music club at 1 a.m. "There I was with Sam Cohn, legendary agent. He had already found Meryl Streep, but he was always looking for new talent."

Both that eye and the excitement that he had for talent stuck with Josephson, who rattles off her clients' accomplishments this past year with maternal pride: Rosie O'Donnell returning to TV with her talk show on OWN; Ricki Lake getting clearance to launch a daytime show next fall; David Crane and Jeffrey Klarik nominated for an Emmy for their Showtime series Episodes; and Cheryl Hines' new series, Suburgatory, premiering to critical and commercial success.

This enthusiasm extends to her home life as well. "It's a big year for me," says the married mother of three children. "I have a son graduating college, a daughter graduating high school and a son graduating elementary school," she says. "So don't call me in June."