THR's Women in Entertainment 2012: Power 100

Josephson, who grew up amid the business as the daughter of ICM founder Marvin Josephson, paved the way for Ricki Lake's return with her daytime talk show and has clients up and down the dial, including So You Think You Can Dance's Cat Deeley, Giuliana Rancic, Craig Ferguson and Tyra Banks, the latter of whom expanded into the publishing space with a three-book deal and young-adult series Modelland.

Moment I knew I wanted to work in the business: Watching my dad work. He would bring clients home; I got to go to dinner with the group Chicago! I remember it being so surreal.

Who gave me my first big break: ICM's Sam Cohn. He worked with Meryl Streep, Sigourney Weaver, E.L. Doctorow -- an amazing client list. He's the one who said I had to come work there, even though I was Marvin's daughter. He took me under his wing and taught me to represent people you're passionate about. I have an eclectic client list, and I got that from Sam.

When I leave work, I can't wait to: Get home to my family. I have one kid left at home and will sit with him for dinner … and then go out for another business dinner.

My indulgence: Great handbags. You can call it an addiction. I tend to splurge. I have that new Celine and love it.

Can't get through my workday without: My assistant, Ellen.

Most surprising song on my iPod: Carly Rae Jepsen's "Call Me Maybe" is such a happy song. It's really more for 12-year-old girls, but whatever.

Proudest moment this year: All three of my children graduated: my son from Stanford, my daughter from high school, and my youngest son is now at Harvard-Westlake. And I managed to keep working the entire time.

Totally starstruck around: Mick Jagger and Bono. I'm insane for both.

What I'd tell my 22-year-old self about working in Hollywood: What I told my son, who's 22: "Always tell the truth. You'll never get in trouble."

Best advice I've ever gotten: From my dad, in a memo he wrote in 1973 that I have at my desk: "Always tell your clients what you're doing for them."

Click here to read THR's complete Women in Entertainment list.