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'Big Bang Theory' Gets Hilarious 'MAD' Send-Up (Exclusive Video)

Leonard and Sheldon swap places with Bert and Ernie as Big Bird turns scientist in a clip from Monday's Cartoon Network series.

The Big Bang Theory's Leonard and Sheldon are about to boldly go where few have gone before: Sesame Street.

CBS' Thursday ratings blockbuster will get the parody treatment during Monday's episode of Cartoon Network's MAD.

PHOTOS: Behind the Scenes: 'The Big Bang Theory'

In an exclusive clip from the episode, the lovable nerds will swap places with a famed Sesame Street duo -- Bert and Ernie -- when Big Bird turns scientist.

MAD -- like Big Bang Theory -- hails from Warner Bros. Television, giving the animated series more creative freedom to roast one of its own.

Check out the clip of The Big Bird Theory, above, and hit the comments on which duo is the most awkward. MAD airs Mondays at 8:30 p.m. on Cartoon Network. The Big Bang Theory airs Thursdays at 8 p.m. on CBS. 

E-mail: Lesley.Goldberg@thr.com; Twitter: @Snoodit