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'Big Bang Theory': Season 6 Promo Teases the Unthinkable for Amy and Sheldon (Video)

Meanwhile, Howard still can't escape his mother even while he's hard at work in space.

Mayim Bialik Jim Parsons Big Bang Theory - H 2012
CBS
"The Big Bang Theory's" Mayim Bialik and Jim Parsons

Are Sheldon and Amy (gasp!) breaking up?

The first promo for the upcoming sixth season of CBS' The Big Bang Theory has arrived and it may not make fans of the couple very happy.

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After boldly going where he's likely never gone before in the fifth season finale and reaching out for Amy's hand in an epic Sheldon show of affection as Howard launched into space, the couple may have some trouble ahead.

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"You and I are done," Amy says to Sheldon as she gets up from what appears to be a romantic night out.

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Meanwhile, Raj is the proverbial third wheel as Howard continues to be tormented by his mother -- even while he's millions of miles away in space.

Check out the promo below and hit the comments with what you'd like to see. The Big Bang Theory premieres Thursday, Sept. 27 at 8 p.m. on CBS.

Email: Lesley.Goldberg@thr.com; Twitter: @Snoodit