‘Scream Queens’ Season 2: All the Details (So Far)

THR presents a primer on what to expect from the Fox anthology when it returns for a second season Sept. 20.

The freshman season of Ryan Murphy’s horror-comedy anthology Scream Queens ended with neck brace-wearing Hester (Lea Michele) literally getting away with murder. Although she was revealed to be the baby in the bathtub, aka Boone’s (Nick Jonas) twin sister and one of the vengeful and murderous Red Devils, Hester ultimately finished the season free as a bird while the Chanels were locked up for her crimes.

Chanel (Emma Roberts), Chanel #3 (Billie Lourd) and Chanel #5 (Abigail Breslin) were sentenced to life in a mental asylum and in the final moments of season one, Chanel was awakened in the middle of the night by a knife-wielding Red Devil — the perfect tease for what’s to come in season two.

Below, The Hollywood Reporter offers a primer of everything to know (so far) about the show’s sophomore run.

Expect to see several familiar faces

The main cast — Jamie Lee Curtis (Dean Munsch), Niecy Nash (Denise Hemphill), Keke Palmer (Zayday Williams), Glen Powell (Chad Radwell), Michele, Roberts, Breslin and Lourd — are all reprising their roles for season two, which will be set in a completely different location.

Bye, Kappa

The majority of season one took place at Wallace University’s Kappa Kappa Tau sorority house, but season two is expected to feature scrubs in favor of designer duds. Season two will be set in a hospital where some of the most fascinating and bizarre medical cases are under observation. And thanks to California’s newly expanded film and TV credit program, the series will also be moving its production from New Orleans to California.

There will be a time jump

Zayday (now a few years older than when viewers saw her last) will fit right into the new setting as a medical school graduate working with Dean Munsch, who, co-creator Brad Falchuk says, has “purchased a hospital.” “All of the girls will be medical students under the rule of Munsch and three hunky doctors,” he added.

Testosterone time

Speaking of hunky docs, John Stamos (Grandfathered) and Taylor Lautner (Twilight) have been added to the season two cast as medical professionals. Stamos is slated to play Dr. Brock Holt, the hospital’s “brilliant but secretive head surgeon,” while Lautner will portray Cassidy Cascade, “a doctor at the hospital who suffers from a strange medical condition and becomes a suspect when a series of tragic events plagues the institution.” Meanwhile, Glee grad James Earl is set to play a character named Candy Striper.

Hester is (probably) not the killer

Since the bathtub baby hacked people into bits in season one, she probably won’t be on a homicidal rampage again in the second season. “I know that Ryan has mentioned that there will be a new killer next year — and it’ll be really funny if everyone thinks it’s Hester, and she’s like, ‘Um, no, actually it’s not me this time.’ And then I think she could be in the position of someone coming after her, which would be really fun to play,” Michele told THR

More horror movie references

As the aforementioned cast of characters tries to figure out who the killer is this time, expect to see some classic horror movie references on the small screen.

Season one paid homage to Psycho’s famous shower scene starring Curtis’ mother, the late Janet Leigh, and apparently there’s much more where that came from. “We definitely will have more,” Falchuk teased. “It’s some of the best moments on the show.”

Scream Queens returns Tuesday, Sept. 20, at 9 p.m. on Fox. Stay tuned to THR's The Live Feed for Scream Queens coverage out of Comic-Con this month.

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