From the Creative Mind of Seth MacFarlane

20th Century Fox/Courtesy of Everett Collection

From cartoons to show tunes, the Family Guy creator continues to expand his empire -- and upend others' expectations.

Family Guy

"Not bad for a show canceled twice" is a popular line within the halls of Family Guy headquarters. At a celebration following another milestone for the series created, written and voiced by MacFarlane,a congratulatory banner from the studio and network read: "Two Cancellations, Zero FCC Fines, Zero Humanitarian Prizes. Congrats on 200 episodes."

American Dad!

Now in its eighth season, American Dad! "has yet to become Family Guy," says MacFarlane of the reception -- and arguably the quality -- of his popular second Fox entry, adding: "If Family Guy is Cheers, American Dad! is Wings."

Comedy Central Roasts

MacFarlane is the network's go-to roast-master, having skewered David Hasselhoff, Donald Trump and, most recently, Charlie Sheen. His early training came during college, when he did stand-up.

The Cleveland Show

The Family Guy spinoff, which was granted a third and fourth season, was co-created and voiced by Mike Henry, whose brother was a classmate of MacFarlane's at RISD. "I'm fortunate to have befriended him," Henry says of MacFarlane, "and even more fortunate that he thought I was funny."

Ted

He co-wrote, produced and directed his first film, out in summer 2012, about an otherwise normal man who keeps a walking, talking teddy bear (voiced by MacFarlane). "It has an enormous amount of heart," he says. "Probably far more than people will be expecting from something to come out of my production and editing."

Music Is Better Than Words

MacFarlane inked a deal with Universal Republic Records, paving the way for the September release of his big band album, which received high praise in The New York Times.

Cosmos: A Space-Time Odyssey

A lifelong passion for science and space exploration brought MacFarlane to the producers of Cosmos, the 1980s PBS series from Carl Sagan to be revived on Fox in 2013.

The Flintstones

Of the series set for 2013, the left-leaning MacFarlane jokes, "I'm the first guy to express reservations about giving the extreme right wing something to point to that shows humans living alongside dinosaurs."

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