Jennifer Lopez-Marc Anthony Split: Hollywood Responds on Twitter

On Friday, news broke that Jennifer Lopez and Marc Anthony were splitting up after seven years of marriage.

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"We have decided to end our marriage. This was a very difficult decision. We have come to an amicable conclusion on all matters," the couple said in a statement issued to several publications.

Lopez and Anthony were married in 2004 and have two children together: Max and Emme. Professionally, the couple is producing the upcoming Latin American competition series Q'Viva (The Chosen).

Anthony is currently recurring on TNT's Hawthorne and serving as a music supervisor on the Jada Pinkett Smith drama, while Lopez most recently served as a judge on Fox's American Idol.

Here are some of Hollywood's reactions to the sudden split:

Alyssa Milano (@Alyssa_Milano): "Anyone else really upset about JLo and Marc Anthony splitting? #SadFace"

Eliza Dushku (@elizadushku): "Whoa. @RollingStone Jennifer Lopez and Marc Anthony are getting divorced."

Julie Benz (@juliebenz): "My relationship advice- never marry a man who has smaller thighs than your own #randomthoughtsinmyhead"

Mindy Kaling (@mindykaling): "(I know you guys are all wondering - I'm just pretending the JLo-Marc Anthony thing isn't happening. Too much. Too much.)"

Giuliana Rancic (@GiulianaRancic): "Yikes!!! Jennifer Lopez and Marc Anthony have split up," before tweeting later, "I feel like this j.lo/marc split came from out of the blue. Remember their super sexy performance on Idol recently? There were no signs."

Neal Brennan (@nealbrennan): "JLo & Marc Anthony announce divorce. JLo to regain full custody of fame she shared with him."

Candace Cameron Bure (@candacecbure): "Seriously sad to read that JLo and Marc Anthony split :("

Keke Palmer (@KekePalmer): "I LOVE @JLo. I mean, I just love her!!"

Wendy Williams (@WendyWilliams): "Just landed & want 2 cry. No I want 2 eat. 2 scream WHY? What I want 2 do most is say it's time for Hot Topics. Marc & JLO getting divorced."

Zack Stentz (@MuseZack), Thor and X-Men: First Class screenwriter: "So according to Twitter, Harry Potter divorces Marc Anthony and gets caught in carmaggeddon?

Derek Blasberg (@derekblasberg), Harpers Bazaar editor at large: "Jennifer Lopez and Marc Antony are getting a divorce. RIP Latin power couple. (But MOST importantly, what will happen to their Kohl's line?)"