Lance Armstrong Might Have Lied to Oprah Winfrey, Investigators Say

Investigators believe that Lance Armstrong might have lied in his highly anticipated interview with Oprah Winfrey during which he admitted to using banned substances, ABC News reported Friday.

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In part one of the interview, which aired Thursday night on OWN, the retired cyclist told Winfrey that he used EPO, testosterone and human growth hormone as well as blood doping or blood transfusions to enhance his performance. The admission came after years of denials and after Armstrong was stripped of his seven Tour de France titles and an Olympics bronze medal.

STORY: Lance Armstrong Admits to Oprah: Yes, I Used Banned Substances

Armstrong also claimed that the last time he used drugs and transitions was for the 2005 race and adamantly denied that he did not do a blood transfusion in 2009 or 2010.

But investigators say that's not true, claiming that his blood values in 2009 show evidence of two transfusions. According to ABC News, his red blood cell count went up suddenly twice, while his baby red blood cells did not. Investigators cite this as evidence that he had a transfusion of mature red blood cells; they say he might have lied to protect himself from a criminal investigation.

Betsy Andreu, who testified that Armstrong had used banned substances, also accused Armstrong of lying about encouraging his teammates on the U.S. Postal Service cycling team to dope. She said his denial left her "disappointed."

“You owed it to me Lance, and you dropped the ball,” she told CNN's Anderson Cooper. “After what you’ve done to me, and what you’ve done to my family.”

STORY: Livestrong Foundation 'Disappointed' That Lance Armstrong 'Misled People'

Elsewhere, the reaction to Armstrong's interview was mostly negative, with many in Hollwood attacking the disgraced cyclist on Twitter.

"Bad day: Spent it on a 787 Dreamliner with Lance Armstrong and Manti Te'o's ex girlfriend," wrote Steve Martin.

And Livestrong Foundation -- the nonprofit organization that Armstrong founded in 1997 to provide support for people affected by cancer -- issued a statement moments after the interview telecast ended, saying it was "disappointed by the news that Lance Armstrong misled people during and after his cycling career, including us."

Part two of Winfrey's interview with Armstrong airs at 9 p.m. Friday.