1. The Coachman (1148 Mission St.) in the Mission District is the newest venture from The Slanted Door's Charles Phan. Dominated by a 30-foot-long slab of cypress that doubles as a bar, the gastropub offers traditional fare with a twist like chips and gravy with black pudding.
2. In the Presidio, The Commissary (101 Montgomery St.) serves such items as fennel and artichoke paella and salt cod fritters in a dining room lined with historical photos.
3. Also in the Mission, Flour + Water (2401 Harrison St.), which has lured locals for five years with house-made pastas and wood-fired pizzas, has reopened following a design refresh.
4. A mural with instructions on how to eat sushi marks the wall at Ichi Sushi + Ni Bar (3282 Mission St.) in Bernal Heights. Opened in February, the casual spot doubles as an izakaya and sushi bar. Instagram CEO Kevin Systrom has stopped by.
5. Located in the Financial District's historic Pacific Telephone Building, Trou Normand (140 New Montgomery St.) features more than 40 types of charcuterie, freshly baked bread and hearty pork belly sandwiches.
6. At Third Rail (628 20th St.) in the Dogpatch District, choose drinks like the Tally Ho with gin, chartreuse and ginger, or try one of nine flavors of house-made beef jerky.
7. In 2012, Sean Penn sounded an alarm when one of his favorite hangouts, the North Beach institution Tosca Cafe (242 Columbus Ave.), was in danger of closing, and he solicited the owners of NYC's Spotted Pig to take it over. Post-refurbish, Tosca retains old-school charm from the Beatnik days. Says Trevor Traina, CEO of IfOnly, an online seller of curated experiences, "The chicken for two is out of this world and worth the 45-minute wait."
8. In nearby Russian Hill, Verbena (2323 Polk St.) draws a crowd of entrepreneurs and advertising executives to its space decked with wooden ladders and a black walnut bar.
9. Also near Union Square, the new Hotel G (386 Geary St.; rooms from $250 a night) features 153 airy guestrooms replete with Danish Modern-inspired furnishings.
10. The 195-room Hotel Palomar (12 Fourth St.; rooms from $569) near Union Square has minibars that can be stocked with gluten-free snacks on request, in-room yoga mats and complimentary guided morning runs.
11. Viceroy Hotel Group's 116-room Hotel Zetta (55 Fifth St.; rooms from $429) near Union Square is a big-kid-at-heart's dream, boasting a playroom with a Nintendo Wii console and life-size Jenga. "I love the hip design and the two-story Plinko game in the lobby you play with soccer balls," says Travis Katz, CEO of the travel site Gogobot.
12. The 134-room Huntington Hotel atop Nob Hill recently reopened as The Scarlet Huntington (1075 California St.; rooms from $459). Head to its librarylike restaurant Big 4 for dinner, or stop by the on-site Nob Hill Spa for a caviar facial.
This story first appeared in the June 6 issue of The Hollywood Reporter magazine.