'The Oranges' Trailer Features Unlikely Couple Hugh Laurie and Leighton Meester (Video)

Hugh Laurie and Leighton Meester aren't strangers.

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The two actors, who play an unlikely couple in the upcoming R-rated indie comedy The Oranges, appeared together in early episodes of Fox's House, where Meester played a patient of the week lusting over the cranky doctor (Laurie). In The Oranges, Laurie and Meester's secret relationship is revealed by a chance trip to a seedy motel that blows everything wide open for both their families. The film follows the aftermath of their affair -- and how it affects everyone around them.

Allison Janney, Adam Brody, Alia Shawkat, Catherine Keener and Oliver Platt co-star in the quirky feature directed by Julian Farino and written by Ian Helfer and Jay Reiss.

THR reviewed The Oranges when it screened at last year's Toronto Film Festival, observing this: "Farino is good with actors, and in his corner he does have a gifted ensemble, who often manage to hit a sweet spot even in this mediocre material."

The Oranges opens in theaters later this year.

Watch the trailer below: