As the Mindy Kaling movie becomes the latest to fizzle in theaters, a confluence of forces — including the streaming service’s push into the arena and the studios’ shift to genres that reap billions worldwide — puts the future of funny films in question.

Ted Danson, Don Cheadle, Henry Winkler and Timothy Simons also open up about why comedy should be dangerous ("I get absolutely terrified — but it becomes addictive"), Hollywood's former drug culture and moving on from indelible roles ("I had no idea how or what to do next").