James Cromwell's Dr. Arden amputates both of Shelley's (Chloe Sevigny) legs when the inmate at the asylum for the "criminally insane" attempts to escape on FX's American Horror Story: Asylum.
STORY: 'American Horror Story': Chloe Sevigny's 5 Most Crypitic Teases on What's Next For Shelley
In awards contender Rust and Bone, Marion Cotillard stars as a whale trainer who loses her legs in an accident.
Grey's Anatomy's Arizona (Jessica Capshaw) is adjusting to life without a leg after her wife Callie (Sara Ramirez) gives the go-ahead for Alex (Justin Chambers) to amputate in a bid to save her life. The pediatrics doc suffered the life-altering injury during the deadly plane crash featured in the ABC drama's season eight season finale.
STORY: 'Grey's Anatomy's' Jessica Capshaw on Arizona's Heartbreaking Loss and What's Next
The Walking Dead's Hershel (Scott Wilson) had his leg brutally cut off with an ax after he was bitten by a walker. Rick (Andrew Lincoln) performs the horrific task in a move to prevent Hershel's transformation into a zombie following the bite.
STORY: 'The Walking Dead's' Robert Kirkman on Hershel's Fate
In the new martial arts actioner The Man With the Iron Fists, the title character played by RZA loses both hands to a torturous amputation.
The Walking Dead's Michael Rooker returns as Merle Dixon, who was last seen on the AMC drama handcuffed to an Atlanta rooftop awaiting certain death. Turns out he used a nearby saw to amputate his own hand and refashion it with a device that helps him keep watch over Woodbury.
Adam Levine's Leo learned early on not to tempt fate when he reached his arm into a mysterious shute, likely home to Bloody Face, on the second season premiere of FX's American Horror Story: Asylum.