Amanda Seyfried Replaces Kate McKinnon in Hulu's Elizabeth Holmes Drama

Amanda Seyfried
Nico Bustos

Amanda Seyfried is headed to Hulu.

The Oscar-nominated Mank actress has been tapped to replace Kate McKinnon and star as Elizabeth Holmes in Hulu's highly anticipated limited series The Dropout.

Based on the ABC News podcast, the limited series traces how Theranos founder Holmes raised hundreds of millions to fund the biotech startup and became a media darling while hiding the fact that her touted blood-testing machine didn't really work. The drama is based on an ABC News podcast of the same name, which also was the basis for a 20/20 episode.

Showrunner Elizabeth Meriwether (New Girl), Liz Heldens (The Passage), Liz Hannah, Katherine Pope, podcast host/ABC News' Rebecca Jarvis, Victoria Thompson and Taylor Dunn exec produce. The series is from Searchlight's TV division and 20th Television. Seyfried will also be credited as a producer on The Dropout.

Seyfried replaces McKinnon in the role. The SNL Emmy winner departed The Dropout last month. The series was poised to begin filming after the NBC sketch comedy favorite wrapped its current season in May. A casting search began immediately after McKinnon dropped out of the series. The Dropout was one of two series McKinnon had lined up outside of SNL. She remains set to star in and exec produce NBCUniversal's Joe Exotic series, which is earmarked for a 2022 debut across NBC, USA and streamer Peacock. McKinnon signed on to The Dropout before boarding Joe Exotic.

Seyfried, nominated for her supporting turn as Marion Davies in Mank, is no stranger to television. She started her career as a regular on As the World Turns and co-starred in HBO's Big Love, with credits that also include Veronica Mars and the 2017 Twin Peaks revival. On the big screen, her credits include Les Misérables, Dear John, Mean Girls, Mamma Mia! Here We Go Again, Scoob and A Milion Ways to Die in the West. She's repped by Innnovative Artists and Frankfurt Kurnit.