VIDEO: Behind the Scenes of THR's Rule Breakers 2011 Magazine Shoot

The issue, out this week, features Kim Kardashian, Kris Jenner, "New Girl," "American Horror Story," "Suburgatory," "Bridesmaids" "The Help," "Two and a Half Men" and more.
Bridgette Sire/Robyn Twomey/Kwaku Alston

Nine months in the making, The Hollywood Reporter's inaugural year-end portfolio of entertainment's biggest risk takers features a who's-who of Hollywood.

STORY: Chuck Lorre's Sheen-Kutcher Gamble, Netflix Gone Awry, Kardashian Brand's 72-Day Wild Ride: THR Features 2011's Biggest Rule Breakers

The 22-page special issue, out this week, includes industry veterans -- George Lucas, James Cameron, Diane Sawyer, Matt Lauer, among others -- TV newcomers Liz Meriweather and Zooey Deschanel of Fox's New Girl as well as Suburgatory's Emily Kapnek and Jane Levy -- and familiar faces, like Kim Kardashian, Kris Jenner and Betheny Frankel.

"I think it's great when a movie like this does well because I hear that women are more than half the population; so shouldn't half of the movies, or 52 percent be like this?" Bridesmaids rule-breaker Judd Apatow jokes during the shoot. Adds star Melissa McCarthy, "I don't know, I can't do numbers!"

PHOTOS: 2011's Biggest Rule Breakers Kim Kardashian, Netflix's Reed Hastings, Chuck Lorre and Ashton Kutcher: THR Year In Review

Go on the creepy set of FX's American Horror Story and visit the Warner Bros. Television lot for Two and a Half Men as THR offers a look behind the scenes of the inaugural Rule Breakers issue.