Oprah, David Letterman Talk Meditation in Her Second 'Late Show' Visit (Video)

The mogul, who next stars in "Lee Daniels' The Butler," last appeared on the talk show in 2005.

Oprah Winfrey is finally back in David Letterman's guest seat on Thursday night's Late Show.

The media mogul makes her second-ever appearance on the CBS late-night talk show, following her first visit in December 2005. She's promoting the filmLee Daniels' The Butler, in which she plays the wife of longtime White House butler Cecil Gaines (Forest Whitaker).

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CBS on Thursday released a preview clip of Winfrey's interview with Letterman, who inquires about her interest in meditation.

"Well, actually, I brought meditation to my whole company … in 2010, because it makes for a better environment when everybody is focused and of one mind and doing well," she revealed.

She then asked Letterman if he meditates, and quickly quipped: "I can tell you don’t. Never mind. I was just asking that. You know, I'm just being polite. I can tell you don't."

Letterman insisted that he does meditate -- and, in fact, he said, "I'm meditating right now." He added that a man called "Meditation Bob" taught the Late Show staff how to meditate over the course of four nights.

"Now, I can meditate anytime I want," he joked.

Winfrey added that she believes "everybody needs to find something. …  And it doesn't matter what you call it, if it's just sitting and being still, if it's reflecting, if it's, you know hugging your children, hugging your dogs, giving some time to that. It's all good."

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Quipped Letterman: "If it's vodka and pills, that's a way to go."

Winfrey added that she is participating in a meditation challenge with Deepak Chopra. People interested in taking part can sign up on her website, Oprah.com.

Watch a clip from Winfrey's appearance below. Late Show airs at 11:35 weeknights on CBS. The Butler hits theaters Aug. 16.