Watch the 'Scream Queens' Opening Credits

The Fox horror-comedy anthology hails from 'American Horror Story's' Ryan Murphy and Brad Falchuk.

Fox is ready to scream.

The network, courtesy of showrunner Ryan Murphy, has released the opening credits for its upcoming horror comedy anthology Scream Queens.

Season one of Scream Queens — set to premiere Tuesday, Sept. 22 at 8 p.m. before moving to its regular slot the following week at 9 p.m. — is set on a college campus that's rocked by a series of murders. Emma Roberts stars as the popular and demanding Chanel Oberlin, the head of sorority Kappa House, with Jamie Lee Curtis portraying the anti-sorority dean, Cathy Munsch. Skyler Samuels portrays Grace Gardner, a pledge looking to bring KKT back to its glory days, who teams with Pete (Diego Boneta) the campus newspaper editor to explore the gruesome murders that take place in the first hour and the mysterious Red Devil killer.

From American Horror Story and Glee masterminds Murphy, Brad Falchuk and Ian Brennan, the series, Murphy told THR, will burn through its characters with only four of its 25 expected to survive the season.

Watch the opening credits, below.