Angelina Jolie Featured on Time Cover After Double Mastectomy (Photo)

Angelina Jolie Time Magazine Cover - P 2013

Angelina Jolie Time Magazine Cover - P 2013

The story looks at the pros and cons of advances in genetic screening.

Angelina Jolie has landed on the cover of Time magazine.

"This week, when a woman known for her powerfully iconic beauty announced that she had undergone an elective double mastectomy to reduce her genetically high risk of breast cancer, it was a cultural and medical earthquake -- a revelation so arresting it became the subject of Time’s newest cover story," writes senior editor Jeffrey Kluger.

Titled "The Angelina Effect," the story examines how Jolie's revelation puts genetic testing -- which found she carried the cancer-related BRCA1 gene -- in the spotlight.  

While the decision is seen as the "right choice for her," Kluger writes, he also cautions that science does "a terrible job of calculation our resulting risks."

"In the U.S., 36 percent of women who do test positive opt for preventive mastectomy, but some doctors argue that regular MRIs and other screening tests may be sufficient to detect the disease," he says.

The issue, on newsstands Friday, is the first cover story featuring the megastar.

Her partner, Brad Pitt, appeared on the cover of the Oct. 13, 1997 issue, in a story titled, "America's Fascination with Buddhism," tied to Seven Years in Tibet.