Box Office: 'Neighbors' Takes Solid $2.6 Million Thursday Night

The Universal comedy starring Seth Rogen, Zac Efron and Rose Byrne will face off against holdover "Amazing Spider-Man 2."

Universal's raunchy comedy Neighbors is off to a strong start, taking in $2.56 million on Thursday night.

The comedy, starring Seth Rogen and Rose Byrne as a young couple with a baby whose life is turned upside down when a loud fraternity moves in next door, opened in 2,224 theaters on Thursday with shows beginning at 8 p.m.

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Also starring Zac Efron as the leader of the frat, Neighbors is directed by Nick Stoller, the filmmaker behind Forgetting Sarah Marshall, Get Him to the Greek and The Five-Year Engagement.

Neighbors was produced by This Is the End team Rogen, Evan Goldberg and James Weaver (Rogen and Goldberg also directed the 2013 end-of-the-world comedy). The trio is producing Neighbors alongside Nathan Kahane and Joe Drake's Good Universe banner.

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The R-rated comedy, which was doing strong advanced ticket sales, will face off this Mother's Day weekend against superhero holdover The Amazing Spider-Man 2.

The Sony film, starring Andrew Garfield and Emma Stone, earned $91.6 million in North America last weekend and has grossed well north of $400 million globally. The Amazing Spider-Man 2 should benefit from Mother's Day more than Neighbors, according to box-office observers.

This weekend's other new films include female Christian comedy Moms' Night Out, starring Patricia Heaton. Industry observers are curious to see whether the comedy gets the same boost that recent faith-based drama titles Heaven Is for Real, God's Not Dead and Son of God have enjoyed.

Twitter: @Beccamford