TMZ reports Heard, 30, filed for divorce on Monday, citing irreconcilable differences. The actress also is reportedly asking for spousal support.
The couple tied the knot at their Los Angeles home in February 2015 after getting engaged in 2012. They first met on the set of 2011’s The Rum Diary.
This marks the second divorce for Depp, 52, who was previously married to makeup artist Lori Anne Allison until their split in 1985. This is Heard’s first divorce.
Depp stars in Disney’s Alice Through the Looking Glass, which opens Friday. Heard most recently starred in The Danish Girl and Magic Mike XXL.
Reps for Heard and Depp did not immediately respond to The Hollywood Reporter‘s requests for comment.