George Lopez, wife end 17-year marriage

Rep: ''The decision is amicable and by mutual agreement'

George Lopez and his wife are going their separate ways.

"George and Ann Lopez have made the decision to end their 17 year marriage," a rep for the "Lopez Tonight" host tells The Hollywood Reporter. "The decision is amicable and by mutual agreement.   They remain dedicated parents, and committed partners in business and their philanthropic organization,  The Lopez Foundation." 

In April 2005, Ann donated one of her kidneys to Lopez, who was battling a genetic condition that caused his organs to fail.

They wed in 1993 and have a 15-year-old daughter named Mayan.

Lopez's late-night show premiered on TBS in 2009. He'll follow Conan O'Brien's show on the same network beginning November 8.

TMZ first reported the story.
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