Gyllenhaal, Hathaway back for 'Love'

'Brokeback' co-stars circling adaptation of Reidy's book

Jake Gyllenhaal and Anne Hathaway, who played a doomed husband and wife in "Brokeback Mountain," are in negotiations to reunite for "Love and Other Drugs" at Fox 2000/New Regency.

Ed Zwick is directing the project (formerly titled "Pharma"), which Charles Randolph ("The Interpreter") adapted from Jamie Reidy's nonfiction book "Hard Sell: The Evolution of a Viagra Salesman."

Reidy was a drug rep for Pfizer in the late 1990s who eventually wrote a memoir that shined a light on the practices of the pharmaceutical industry. Gyllenhaal will play the salesman, who begins a relationship with a woman who has Parkinson's (Hathaway) while on one of his sales calls. Their love story plays out in the political and social context of the time.

Zwick and his Bedford Falls partner Marshall Herskovitz are producing along with Scott Stuber, who originated the project. Randolph is also producing. Carla Hacken is overseeing for Fox 2000, Kara Francis for New Regency.

Fox is in the process of obtaining the rights from Universal, which had put the project into turnaround. The filmmakers hope to begin shooting in the fall.

Hathaway also had been considering filling Reese Witherspoon's role in "Tokyo Suckerpunch" at Sony but can't match schedules with would-be co-star Tobey Maguire, who shoots "Spider-Man 4" next year.

Hathaway has "Alice in Wonderland" moving toward a March release and "Get Smart 2" scheduled to film in May, with co-star Steve Carell working on the script.

Gyllenhaal has the David O. Russell-directed "Nailed" in postproduction and Disney's video game adaptation "Prince of Persia: The Sands of Time" hitting theaters in May.

Gyllenhaal and Hathaway are repped by CAA and Management 360.

The CAA-repped Zwick most recently directed "Defiance," which he also co-wrote.