Jennifer Lopez-Marc Anthony Split: Hollywood Responds on Twitter

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"Anyone else really upset about JLo and Marc Anthony splitting?," actress Alyssa Milano tweeted after the news broke.

On Friday, news broke that Jennifer Lopez and Marc Anthony were splitting up after seven years of marriage.

"We have decided to end our marriage. This was a very difficult decision. We have come to an amicable conclusion on all matters," the couple said in a statement issued to several publications.

Lopez and Anthony were married in 2004 and have two children together: Max and Emme. Professionally, the couple is producing the upcoming Latin American competition series Q'Viva (The Chosen).

Anthony is currently recurring on TNT's Hawthorne and serving as a music supervisor on the Jada Pinkett Smith drama, while Lopez most recently served as a judge on Fox's American Idol.

Here are some of Hollywood's reactions to the sudden split:

Alyssa Milano (@Alyssa_Milano): "Anyone else really upset about JLo and Marc Anthony splitting? #SadFace"

Eliza Dushku (@elizadushku): "Whoa. @RollingStone Jennifer Lopez and Marc Anthony are getting divorced."

Julie Benz (@juliebenz): "My relationship advice- never marry a man who has smaller thighs than your own #randomthoughtsinmyhead"

Mindy Kaling (@mindykaling): "(I know you guys are all wondering - I'm just pretending the JLo-Marc Anthony thing isn't happening. Too much. Too much.)"

Giuliana Rancic (@GiulianaRancic): "Yikes!!! Jennifer Lopez and Marc Anthony have split up," before tweeting later, "I feel like this j.lo/marc split came from out of the blue. Remember their super sexy performance on Idol recently? There were no signs."

Neal Brennan (@nealbrennan): "JLo & Marc Anthony announce divorce. JLo to regain full custody of fame she shared with him."

Candace Cameron Bure (@candacecbure): "Seriously sad to read that JLo and Marc Anthony split :("

Keke Palmer (@KekePalmer): "I LOVE @JLo. I mean, I just love her!!"

Wendy Williams (@WendyWilliams): "Just landed & want 2 cry. No I want 2 eat. 2 scream WHY? What I want 2 do most is say it's time for Hot Topics. Marc & JLO getting divorced."

Zack Stentz (@MuseZack), Thor and X-Men: First Class screenwriter: "So according to Twitter, Harry Potter divorces Marc Anthony and gets caught in carmaggeddon?

Derek Blasberg (@derekblasberg), Harpers Bazaar editor at large: "Jennifer Lopez and Marc Antony are getting a divorce. RIP Latin power couple. (But MOST importantly, what will happen to their Kohl's line?)"