Watch Joe Biden Deliver Impassioned Plea Against Donald Trump at DNC

"I've been made strong by the broken places," said the Vice President while remembering his late son and speaking to the other "unbreakable" spirits. While passionately endorsing Hillary Clinton, he slammed Donald Trump's inexperience to a rapt Democratic National Convention on Wednesday.

Vice President Joe Biden kicked off Wednesday night's headliners at the Democratic National Convention in Philadelphia with a personal and passionate speech applauding the "unbreakable" spirit of the American people and attacking Donald Trump.

"This is kind of a bittersweet moment for Jill and me and our family," he said, speaking to others who have suffered from tragedy while recalling his late son. "In 2008, our son Beau introduced me to the country and placed my name into nomination. You got a glimpse at what an incredibly fine young man Beau was."

Quoting Ernest Hemingway, Biden said, "I've been made strong by the broken places."

Passionately endorsing Hillary Clinton, he spoke about the world he grew up in compared to today.

"My daughters and granddaughters can do anything our sons and grandsons can do," said Biden. "Hillary Clinton is always there, she's always been there. And so has Tim Kaine."

He then asked the crowd to pause their chants to listen carefully before saying, "That's not Donald Trump's story."

"His cynicism is unfounded," said Biden, harping on Trump's negative Apprentice catchphrase of "You're fired" and lack of knowledge about the middle class and national security. "How can there be pleasure in saying, 'You're fired'?"

Recalling his own nickname of "Middle Class Joe," he slammed Trump's inability to fight for the middle class.

"He has no clue about what makes America great," said Biden. "Actually, he has no clue, period."

The Vice President again attempted to calm the rousing crowd to deliver more pointed words: "No major-party nominee in the history of this nation has ever known less or has been less prepared.

"We lead not only by the example of our power, but by the power of our example."

After telling the crowd, "I love you," as they stood to their feet in ovation when he ran out to the stage, Biden called Barack Obama "one of the finest presidents we've ever had" and said he had "become a brother" to him and his wife.

"And Michelle, I don't know where you are, kid, but you are incredible," he said, adding that the first lady already gave the best speech of the convention. "Barack and I married way up, way up."

Biden was introduced by his wife, Jill, who said it's been "an honor" to serve as second lady of the U.S. for the last eight years and called her husband "honest and strong, principled and compassionate." She continued, "He was authentic long before it became a buzzword in politics."

Even after all he's been through, he remains "the most optimistic person I know," she added.

A video introducing the Vice President then played before Biden took the stage. His efforts to legalize same-sex marriage and end sex abuse on college campuses earned the loudest cheers from inside the room in Philadelphia.

Headlining the third night of the four-day convention are Clinton's VP pick Kaine and President Obama. Wednesday also saw speeches from Angela Bassett, Empire's Lee Daniels and a performance from Lenny Kravitz. Sigourney Weaver introduced a climate change film directed by James Cameron that took aim at Donald Trump, and Christine Leinonen, the mother of one of the Orlando victims, brought the room to tears.

The DNC has had no shortage of A-list support in Philadelphia. On Tuesday night, Kesha performed at a gun-control concert and on Wednesday night, Fergie will headline a concert for the Creative Coalition and the Black Eyed Peas headlined the Rock The Vote concert at the Fillmore.

Susan Sarandon, Shailene Woodley, Rosario Dawson and Shonda Rimes have all been spotted at the DNC, in addition to the impressive roster of celebrity speakers. Last night, Meryl Streep, Lena Dunham and America Ferrera and Tony Goldwyn spoke, while Elizabeth Banks hosted and former President Bill Clinton headlined.

Watch Biden's full speech below.