The trailblazer talked to THR last fall about her dreams, victories and challenges.

Laura Ziskin's career in film and TV spanned nearly three decades, moving from down-home dramas to comic-book spectaculars.

Murphy's Romance (1985)
Starring Sally Field, James Garner
Directed by Martin Ritt

No Way Out (1987)
Starring Kevin Costner, Sean Young
Directed by Roger Donaldson

D.O.A.  (1988)
Starring Dennis Quaid, Meg Ryan
Directed by Annabel Jankel, Rocky Morton

Everybody's All-American (1988)
Starring Jessica Lange, Dennis Quaid
Directed by Taylor Hackford

Pretty Woman (1990)(executive producer)
Starring Richard Gere, Julia Roberts
Directed by Garry Marshall

What About Bob? (1991)
Starring Bill Murray, Richard Dreyfuss
Directed by Frank Oz

The Doctor (1991)
Starring William Hurt, Christine Lahti
Directed by Randa Haines

Hero (1992)
Starring Dustin Hoffman, Geena Davis
Directed by Stephen Frears

To Die For (1995)
Starring Nicole Kidman, Matt Dillon
Directed by Gus Van Sant

As Good As It Gets (1997)(executive producer)
Starring Jack Nicholson, Helen Hunt
Directed by James L. Brooks

Fail Safe (2000) (executive producer)
Starring George Clooney, Richard Dreyfuss
Directed by Stephen Frears

The 74th Annual Academy Awards (2002)
Directed by Louis J. Horvitz

Spider-Man (2002)
Starring Tobey Maguire, Kirsten Dunst
Directed by Sam Raimi

Spider-Man 2 (2004)
Starring Tobey Maguire, Kirsten Dunst
Directed by Sam Raimi

Stealth (2005)
Starring Josh Lucas, Jessica Biel
Directed by Rob Cohen

The 79th Annual Academy Awards (2007)
Directed by Louis J. Horvitz

Spider-Man 3 (2007)
Starring Tobey Maguire, Kirsten Dunst
Directed by Sam Raimi

Stand Up to Cancer (2008, 2010) (executive producer)

The Amazing Spider-Man (2012)
Starring Andrew Garfield, Emma Stone
Directed by Marc Webb