Luke Wilson, Diane Ladd join HBO pilot

Duo cast opposite Laura Dern in the comedy 'Enlightened'

Luke Wilson and Diane Ladd are set to star opposite Laura Dern in her HBO comedy pilot "Enlightened."

Also cast in Mike White's single-camera pilot are Amy Hill as a regular and Charles Esten as a recurring.

The project stars Dern as Amy, a self-destructive woman who after a meltdown has a spiritual awakening and becomes determined to live an enlightened life, creating havoc at home and work.

In his first regular TV gig, Wilson will play Levi, Amy's unkempt ex-husband who has a drug problem.

Dern's real life mom, Ladd, will play Amy's mother, who takes in her daughter as a house guest after her crisis.

Hill will play the head of human resources at Amy's workplace. Esten will play Amy's boss and former lover who triggers her meltdown when he has her transferred.

Wilson's only significant TV appearance was a recurring role on Fox's comedy "That '70s Show," in which he played the older brother of Ashton Kutcher's character. The CAA-repped Wilson next appears in the feature comedy "Death at a Funeral."

Ladd and Dern have co-starred together in nine feature and TV movies, including the 1991 film "Rambling Rose," which earned them Academy Award noms -- the first time a mother and daughter received Oscar noms for the same movie.

"Enlightening" also marks the fifth time Ladd will play Dern's onscreen mother following the features "White Lightning" (1973), "Wild at Heart" (1990), "Citizen Ruth" (1996) and "Daddy and Them" (2001).

Hill ("Couples Retreat") is with SMS Talent. The Stone Manners-repped Esten recurred last season on HBO's "Big Love."

Wilson, Ladd, Hill and Esten join previously cast regular Sarah Burns.