'Red Dead Redemption' Tops Spike TV's Video Game Awards

'Red Dead Redemption' - Video Screen Grab

The Wild West epic nabs four trophies, including game of the year; Neil Patrick Harris also a winner.

Red Dead Redemption took home top honors at Spike TV's Video Game Awards.

The Wild West epic rounded up four trophies at Saturday's show in Los Angeles, including game of the year. Redemption -- from Rockstar Games, which is also behind the controversial Grand Theft Auto series -- also won VGAs for best song, best original score and best downloadable content.

Other multiple honorees at the eighth annual event were BioWare/Electronic Arts' Mass Effect 2, which won best Xbox 360 game and two other prizes; and Sony's God of War III, whose two prizes included best PlayStation 3 game.

The program was hosted by Neil Patrick Harris, who won the award for best performance by a human male for voicing Peter Parker and Spider-Man in Activision's Spider-Man: Shattered Dimensions.

The Associated Press contributed to this report.