Steven Tyler Performs at 'Race to Erase MS' Gala

Steven Tyler Season 11 Top 13 Party P
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The fundraiser, which honored Dean Singleton for his battle against MS, also featured performances by Cee Lo Green and Natalie Cole.

Steven Tyler, Cee Lo Green and Natalie Cole entertained at the 21st Annual Race to Erase MS Gala at the Hyatt Regency in Los Angeles on Friday.

Guests jumped to their feet and sang along when Tyler performed Aerosmith hits including "Walk this Way" and "Jaded." Tyler was later joined by Cole for an unrehearsed duet of "I Don't Want to Miss a Thing."

Race to Erase MS founder Nancy Davis expressed that seeing her fundraiser come to fruition every year feels "like giving birth to a healthy baby." Davis started the organization in 1993, the same year that the first drug to treat multiple sclerosis was approved.

"It started with a dream," said Davis. "It hits you really in the prime of your life when you're just starting to get your stride, so it's exciting giving those people back their lives and giving a lot of children their parents."

Tyler said he wanted to show his support for Davis and an organization that is close to his heart.

"It means everything to me," the musician told The Hollywood Reporter. "Nancy called me up and said, 'Aren't you glad to erase MS'? and I said, 'I'll be sad if I didn't.'"

Natalie Cole added of the founder: "One of the reasons why me and Nancy have a friendship is because we've both been through so many challenges. It's really helped me to become the woman I am. It's really the hard stuff that develops you."

MediaNews Group founder Dean Singleton was honored with the Medal of Hope Award and expressed his strong belief that the world is getting closer to finding a cure.

"If I were diagnosed today at the age I was diagnosed with first, we could stop it in its tracks," said Singleton. "We're on the verge of being able to repair the damage so that old cooks like me have a chance to walk again, and damn it I'm going to walk again."

Stars including Randy Jackson joined Cole and Tyler onstage to continue the tradition of ending the evening singing "Lean on Me."

Tyler brought Davis' young daughters onstage and reminded them that they were not alone on the road to curing their mother and the many others who suffer from MS.

"We're going to fight this disease," said Tyler. "It's about making a wish and making your dreams come true."

MS sufferer Jack Osbourne, Kelly Osbourne, musician Jordin Sparks and Dancing With the Stars' Cheryl Burke were also in attendance.